MwPharm++ Release - Description
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MwPharm++ Release - Description

MwPharm++/Edsim++ Release - Description

  • Updated: If XScaler operates in absolute mode, the fields related to the reference value should be hidden (Mref, Vref, Vthr)
  • Updated: The simulation of models containing TWeibull inputs is sometimes truncated (not with TGamma and TGaussian)
  • Updated: TPolyExp stand-alone mode may throw top level exceptions in stand-alone mode (AutoInit = No)
  • Fixed: XCovariate CoFactors are not properly updated in the GUI after change the scaler variable. Simulated values were ok.
  • Fixed: XCovariate CoFactors are not properly initialized at simulation start (t=0). Simulated values were ok.
  • Fixed: The visualized covariate chain should prefer the route via ExFactor if more routing options are available
  • Fixed: Fixed line width issue (thick lines) caused by windows update KB006670. Removing this update is no longer required
  • Fixed: Illegal characters like spaces and brackets prevents the model from being saved in XML format without warning
  • Fixed: Selecting multiple objects in Edsim++ is very slow
  • Fixed: Loading dose optimization failed for non-optimal regimens due to error in analyzer output event logic.
  • Fixed: The enabling of FPU-exceptions exposed an overflow problem in TSynergism
  • Fixed: Long symbol descriptions are truncated (pop-up window height must grow).
  • Fixed: Loading dose option "NONE" should also apply to constant rate infusions (see CR-334)
  • Fixed: Any tool object (e.g. TIntegrator, XObserved) can now be directly connected (as source) to effect objects like TSigmoid
  • Added: Added 2 baseline modes to TSigmoid. BaselineUP: E = E0 * (1 + Emax * S). BaselineDN: E = E0 * (1 - Emax * S).
  • Added: Added external modulation factor Kmod to QInput\QOutput in case Kin or Kout is a calculated value
  • Added: Add TPeripheralEx compartment with alternative volume parametrization (Vss and FV1)
  • Added: Added Fb (see XMatExpPna) parameter to XMaturation. Fractional decrease exponential term at zero driver age (PNA, PMA).
  • Added: Merge model and merge metabolite now preserve the layout of the existing (parent) model
  • Added: Direct (TSigmoid) and indirect (QResponse) effects can now be connect to covariate scaling object (e.g. XScaler)
  • Added: Allow TPolyExp to be connected to a TVirtual(Linked) compartment
  • Added: Added units for virus amounts and concentrations (vg = vector genomes, G=giga=10^9, T=tera=10^12, P=peta=10^15)
  • Added: Added TBodyWeight tool object for alternative LBM-IBW-FFM formulas
  • Added: Added Tlevel mode to TAbsorptionNL for modeling bioavailability depending on the interval time (renamed Level to Dlevel)
  • Added: Added Dose quantity using a default unit of mg/kg
  • Added: Allow negative slope parameter (Preg) in XRegession. Added option for positive or negative slope
  • Added: The tumor modeling objects ZCytostatic and ZCytotoxic can now use TIntegrator objects as a source (AUC effect driver)
  • Added: Added XResistance for modeling the time dependent exponential decrease of drug effect (Emax modulator)
  • Added: Unused parameters in ZCytotoxic (mode dependent, linear vs sigmoidal) are now not only read-only but also hidden
  • Added: Added AUCIN variable to TIntegrator which is the AUC calculated after an interval
  • Added: A 0-dose event will update the integrator output and suspends integration until the next dose > 0 event in case Zdos="Yes"
  • Added: The Object.Event method is now called for both ON and OFF (new) events while passing in the event object
  • Added: The PrntScrn and F2 keys now save a screen shot (sequentially number) in the Screens folder. View in combination with SHIFT
  • Added: The XScaler threshold is now applied in relative and absolute (new) mode
  • Added: The load optimizer now uses the LTarget setting (NONE, MIN, MAX, AUTO (AVE), OPTIMAL (Profile-based))
  • Added: The load calculation for continuous infusions now uses the LTarget setting (NONE, MIN, MAX, AUTO (AVE), OPTIMAL (AVE))
  • Added: In addition to fitted normalize parameters, the export library not also exports denormalized parameters
  • Added: Enabled FPU-exceptions (overflow, underflow) in Edsim++ in order to avoid unrecoverable model corruption with NAN values
  • Added: In addition to creatinine, Cystatin-C (Ccy) and creatinine clearance (CLcr) are now also exported by the export library
  • Added: Added non-parametric confidence interval calculation to statistics module (see CR-418) required for bootstrap distribution analysis


MwPharm++ is an efficient TDM software primarily to establish proper dosing regimen based on population PK.

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MwPharm Online Calculator is ideal tool for initial dose adjustment based on patient physiology and approate package size selection.

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Health insurance

MwPharm Revision System enables better control, more effective treatment and cost savings.

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Research & university

Research or teaching on PKPD? Edsim++ is ideal tool for you.

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