MEDIWARE a.s.
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160 00 Praha 6
Tel: +420 773 760 568
Email: support@mediware.cz
MwPharm won critical acclaim in 2013 and was awarded the world's best TDM software:
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Proost JH, Meijer DK.: MW/Pharm, an integrated software package for drug dosage regimen calculation and therapeutic drug monitoring. Comput Biol Med. 1992 May;22(3):155-63.
Neef C, Jelliffe RW, van Laar T, Loohuis T, Essink AW, Janssen EN.: Comparison of two software programs to be used for the calculation of population pharmacokinetic parameters. Int J Biomed Comput. 1994 Jun;36(1-2):143-50.
Mouton JW, Vinks AA, Punt NC.: Pharmacokinetic-pharmacodynamic modeling of activity of ceftazidime during continuous and intermittent infusion. Antimicrob Agents Chemother. 1997 Apr;41(4):733-8.
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Alffenaar JW, Kosterink JG, van Altena R, van der Werf TS, Uges DR, Proost JH.: Limited sampling strategies for therapeutic drug monitoring of linezolid in patients with multidrug-resistant tuberculosis. Ther Drug Monit. 2010 Feb;32(1):97-101. doi: 10.1097/FTD.0b013e3181cc6d6f.
Kerkhofs T, Derijks L, Ettaieb M, den Hartigh J, Neef C, Gelderblom H, Guchelaar HJ, Haak H.: Development of a Pharmacokinetic Model of Mitotane: Towards Personalized Dosing in Adrenocortical Carcinoma. Ther Drug Monit. 2014 May 30.
Ter Laak MA, Roos C, Touw DJ, van Hattum PR, Kwee A, Lotgering FK, Mol BW, van Pampus MG, Porath MM, Spaanderman ME, van der Post JA, Papatsonis DN, van 't Veer NE.: Pharmacokinetics of nifedipine slow-release during sustained tocolysis. Int J Clin Pharmacol Ther. 2014 Nov 19.
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Pullen J, de Rozario L, Stolk LM, Degraeuwe PL, van Tiel FH, Zimmermann LJ.: Population pharmacokinetics and dosing of flucloxacillin in preterm and term neonates. Ther Drug Monit. 2006 Jun;28(3):351-8.
Cremers SC, Scholten EM, Schoemaker RC, Lentjes EG, Vermeij P, Paul LC, den Hartigh J, de Fijter JW.: A compartmental pharmacokinetic model of cyclosporin and its predictive performance after Bayesian estimation in kidney and simultaneous pancreas-kidney transplant recipients. Nephrol Dial Transplant. 2003 Jun;18(6):1201-8.
Valik D, Sterba J, Bajciova V, Demlova R.: Severe encephalopathy induced by the first but not the second course of high-dose methotrexate mirrored by plasma homocysteine elevations and preceded by extreme differences in pretreatment plasma folate. Oncology. 2005;69(3):269-72. Epub 2005 Sep 15.
Worrall SP, Almond MK, Dhillon S.: Pharmacokinetics of bupropion and its metabolites in haemodialysis patients who smoke. A single dose study. Nephron Clin Pract. 2004;97(3):c83-9.
Schreuder MF, Wilhelm AJ, Bökenkamp A, Timmermans SM, Delemarre-van de Waal HA, van Wijk JA.: Impact of gestational age and birth weight on amikacin clearance on day 1 of life. Clin J Am Soc Nephrol. 2009 Nov;4(11):1774-8. doi: 10.2215/CJN.02230409. Epub 2009 Aug 27.
Alffenaar JW, Nienhuis WA, de Velde F, Zuur AT, Wessels AM, Almeida D, Grosset J, Adjei O, Uges DR, van der Werf TS.: Pharmacokinetics of rifampin and clarithromycin in patients treated for Mycobacterium ulcerans infection. Antimicrob Agents Chemother. 2010 Sep;54(9):3878-83. doi: 10.1128/AAC.00099-10. Epub 2010 Jun 28.
Usman M, Ashraf M, Khokhar MI, Ashiq B, Masood MI, Afzal S, Omer O, Ali M, Qadir MI.: Comparative pharmacokinetics of levofloxacin in healthy volunteers and in patients suffering from typhoid Fever. Iran J Pharm Res. 2013 Winter;12(1):147-54.
Haeseker MB, Croes S, Neef C, Bruggeman CA, Stolk LM, Verbon A.: Vancomycin dosing in neutropenic patients. PLoS One. 2014 Nov 12;9(11):e112008. doi: 10.1371/journal.pone.0112008. eCollection 2014.
Haeseker M, Havenith T, Stolk L, Neef C, Bruggeman C, Verbon A.: Is the standard dose of amoxicillin-clavulanic acid sufficient? BMC Pharmacol Toxicol. 2014 Jul 21;15:38. doi: 10.1186/2050-6511-15-38.
Haeseker M, Stolk L, Nieman F, Hoebe C, Neef C, Bruggeman C, Verbon A.: The ciprofloxacin target AUC : MIC ratio is not reached in hospitalized patients with the recommended dosing regimens. Br J Clin Pharmacol. 2013 Jan;75(1):180-5. doi: 10.1111/j.1365-2125.2012.04337.x.
Pullen J, Stolk LM, Degraeuwe PL, van Tiel FH, Neef C, Zimmermann LJ.: Pharmacokinetics of intravenous rifampicin (rifampin) in neonates. Ther Drug Monit. 2006 Oct;28(5):654-61.
Stolk LM, Degraeuwe PL, Nieman FH, de Wolf MC, de Boer A.: Population pharmacokinetics and relationship between demographic and clinical variables and pharmacokinetics of gentamicin in neonates. Ther Drug Monit. 2002 Aug;24(4):527-31.
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Alsaad, N., Dijkstra, J.A., Akkerman, O.W., De Lange, W.C.M., Van Soolingen, D., Kosterink, J.G.W., Van Der Werf, T.S., Alffenaar, J.W.C. Pharmacokinetic evaluation of sulfamethoxazole at 800 milligrams once daily in the treatment of tuberculosis (2016) Antimicrobial Agents and Chemotherapy, 60 (7), pp. 3942-3947. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976877588&doi=10.1128%2fAAC.02175-15&partnerID=40&md5=b4f03fc8cba4ae2f2dc60bd1d553901d DOI: 10.1128/AAC.02175-15 DOCUMENT TYPE: Article SOURCE: Scopus Khan, I.M., Khan, B.T., Najmi, M.H., Sabah, S., Ahmed, T. Bioequivalence study of atorvastatin by HPLC with UV-detection (2016) Rawal Medical Journal, 41 (3), pp. 354-359. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84989229088&partnerID=40&md5=2fc034f0f70fc0cb6c9c308e8469f518 DOCUMENT TYPE: Article SOURCE: Scopus Koudijs, K.K.M., Moes, D.J.A.R., Den Hartigh, J. Interfacing MW\Pharm to a laboratory information system calculates aucs of immunosuppressants with fewer errors and in less time [Koppeling van MW\Pharm aan een laboratoriuminformatiesysteem vermindert foutgevoeligheid en verbetert efficiëntie bij berekening van concentratietijdgrafieken van immunosuppressiva] (2015) Pharmaceutisch Weekblad, 150 (47), pp. 250-252. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84951143032&partnerID=40&md5=1176a2db3afa0aeb76ab51794c7c41f4 DOCUMENT TYPE: Article SOURCE: Scopus Grundmann, M., Kacířová, I. Personalized pharmacotherapy of digoxin [Personalizovaná farmakoterapie digoxinem] (2015) Vnitrni Lekarstvi, 61 (5), pp. 406-409. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84932167167&partnerID=40&md5=713cfe2a75b08d35338629c82004891b DOCUMENT TYPE: Article SOURCE: Scopus Grundmann, M., Kacířová, I. TDM of digoxin in clinical practice [TDM digoxinu v klinické praxi] (2015) Kardiologicka Revue, 17 (1), pp. 65-69. Cited 1 time. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926344521&partnerID=40&md5=880f1c235913ed590f8954894a2b7ff3 DOCUMENT TYPE: Article SOURCE: Scopus Van Den Hurk, G.H.A.M., Janssen, J.M., Juffermans, N.P., Van Hest, R.M. Quality of dosing recommendations during therapeutic drug monitoring of aminoglycosides at the Intensive Care Unit [De kwaliteit van doseringsadviezen bij therapeutic drug monitoring van aminoglycosiden op de intensive care] (2015) Pharmaceutisch Weekblad, 150 (34-35), pp. 160-164. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84941112067&partnerID=40&md5=7d62f3940fc0dd57aae6ece48aac6376 DOCUMENT TYPE: Article SOURCE: Scopus Gist, K.M., Mizuno, T., Goldstein, S.L., Vinks, A. Retrospective evaluation of milrinone pharmacokinetics in children with kidney injury (2015) Therapeutic Drug Monitoring, 37 (6), pp. 792-796. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84947904246&doi=10.1097%2fFTD.0000000000000214&partnerID=40&md5=e3fa2766922d6b42fbd899b0ed3ea76d DOI: 10.1097/FTD.0000000000000214 DOCUMENT TYPE: Article SOURCE: Scopus Haeseker, M.B., Croes, S., Neef, C., Bruggeman, C.A., Stolk, L.M.L., Verbon, A. Vancomycin dosing in neutropenic patients (2014) PLoS ONE, 9 (11), art. no. e112008, . Cited 4 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84911440150&doi=10.1371%2fjournal.pone.0112008&partnerID=40&md5=566435e854226f885f09641349520496 DOI: 10.1371/journal.pone.0112008 DOCUMENT TYPE: Article SOURCE: Scopus Liu, H., Venkatraman, S.S. Solid/Hollow depots for drug delivery, Part 1: Effect of drug characteristics and polymer molecular weight on the phase-inversion dynamics, depot morphology, and drug release (2014) Journal of Pharmaceutical Sciences, 103 (2), pp. 485-495. Cited 1 time. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84895918293&doi=10.1002%2fjps.23790&partnerID=40&md5=05abd00c0367389bd4995922b92ca32a DOI: 10.1002/jps.23790 DOCUMENT TYPE: Article SOURCE: Scopus Haeseker, M., Havenith, T., Stolk, L., Neef, C., Bruggeman, C., Verbon, A. Is the standard dose of amoxicillin-clavulanic acid sufficient? (2014) BMC Pharmacology and Toxicology, 15 (1), art. no. 38, . Cited 6 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926111343&doi=10.1186%2f2050-6511-15-38&partnerID=40&md5=6f6dc5246f6eb14fb8f2a9bf5b8f95f0 DOI: 10.1186/2050-6511-15-38 DOCUMENT TYPE: Article SOURCE: Scopus Chooi, K.W., Simão Carlos, M.I., Soundararajan, R., Gaisford, S., Arifin, N., Schätzlein, A.G., Uchegbu, I.F. Physical characterisation and long-term stability studies on quaternary ammonium palmitoyl glycol chitosan (GCPQ) - A new drug delivery polymer (2014) Journal of Pharmaceutical Sciences, 103 (8), pp. 2296-2306. Cited 7 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905126758&doi=10.1002%2fjps.24026&partnerID=40&md5=b2f259115ed3fc131851df93de34b8b7 DOI: 10.1002/jps.24026 DOCUMENT TYPE: Article SOURCE: Scopus Usman, M., Ashraf, M., Khokhar, M.I., Ashiq, B., Masood, M.I., Afzal, S., Omer, O., Ali, M., Imran Qadir, M. Comparative pharmacokinetics of levofoxacin in healthy volunteers and in patients suffering from typhoid fever (2013) Iranian Journal of Pharmaceutical Research, 12 (1), pp. 147-154. Cited 2 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84874685924&partnerID=40&md5=78c61391052b17e24e89c57ee0b56300 DOCUMENT TYPE: Article SOURCE: Scopus Cabrales, A., Gil, J., Fernández, E., Valenzuela, C., Hernández, F., García, I., Hernández, A., Besada, V., Reyes, O., Padrón, G., Berlanga, J., Guillén, G., González, L.J. Pharmacokinetic study of Growth Hormone-Releasing Peptide 6 (GHRP-6) in nine male healthy volunteers (2013) European Journal of Pharmaceutical Sciences, 48 (1-2), pp. 40-46. Cited 5 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84869869341&doi=10.1016%2fj.ejps.2012.10.006&partnerID=40&md5=e75fa0c4cf94b87b8b312fd306beb7f2 DOI: 10.1016/j.ejps.2012.10.006 DOCUMENT TYPE: Article SOURCE: Scopus Boone, N.W., Stolk, L.M.L., Degraeuwe, P.L.J., Neef, C. Population pharmacokinetics of indometacin for prophylactic treatment of patent ductus arteriosus directly after birth of very young premature infants [Populatiekinetiek van indometacine bij profylactische behandeling van patent ductus arteriosus direct na de geboorte van zeer jonge prematuren] (2013) Pharmaceutisch Weekblad, 148 (3), pp. 6-9. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872938102&partnerID=40&md5=1ed1689b96496adb6d0bbfe2061eb581 DOCUMENT TYPE: Article SOURCE: Scopus Haeseker, M., Stolk, L., Nieman, F., Hoebe, C., Neef, C., Bruggeman, C., Verbon, A. The ciprofloxacin target AUC: MIC ratio is not reached in hospitalized patients with the recommended dosing regimens (2013) British Journal of Clinical Pharmacology, 75 (1), pp. 180-185. Cited 8 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84871124488&doi=10.1111%2fj.1365-2125.2012.04337.x&partnerID=40&md5=8cea52eb9dfc223d6d7edd5146238616 DOI: 10.1111/j.1365-2125.2012.04337.x DOCUMENT TYPE: Article SOURCE: Scopus Marsot, A., Boulamery, A., Bruguerolle, B., Simon, N. Population pharmacokinetic analysis during the first 2 years of life: An overview (2012) Clinical Pharmacokinetics, 51 (12), pp. 787-798. Cited 17 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873456965&doi=10.1007%2fs40262-012-0015-8&partnerID=40&md5=9e2cd61f55d1e6f5f819dcabe27d1269 DOI: 10.1007/s40262-012-0015-8 DOCUMENT TYPE: Review SOURCE: Scopus Zahálková, J., Strojil, J., Petejová, N., Urbánek, K., Grundmann, M., Kacířová, I. Dosage of vancomycin during continuous renal replacement therapy [Dávkování vankomycinu při kontinuální náhradě funkce ledvin] (2011) Klinicka Farmakologie a Farmacie, 25 (3), pp. 116-120. Cited 4 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-84855650162&partnerID=40&md5=17c58b8a95bc90184bc972e22dadca14 DOCUMENT TYPE: Article SOURCE: Scopus Imamura, K., Yokoyama, T., Fukushima, A., Kinuhata, M., Nakanishi, K. Water sorption, glass transition, and protein-stabilizing behavior of an amorphous sucrose matrix combined with various materials (2010) Journal of Pharmaceutical Sciences, 99 (11), pp. 4669-4677. Cited 5 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-78149315856&doi=10.1002%2fjps.22162&partnerID=40&md5=e6f5e381dfc16757b3757f3209cfe3ac DOI: 10.1002/jps.22162 DOCUMENT TYPE: Article SOURCE: Scopus Alffenaar, J.W.C., Nienhuis, W.A., De Velde, F., Zuur, A.T., Wessels, A.M.A., Almeida, D., Grosset, J., Adjei, O., Uges, D.R.A., Van Der Werf, T.S. Pharmacokinetics of rifampin and clarithromycin in patients treated for Mycobacterium ulcerans infection (2010) Antimicrobial Agents and Chemotherapy, 54 (9), pp. 3878-3883. Cited 22 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-77956109968&doi=10.1128%2fAAC.00099-10&partnerID=40&md5=f5796d7d132bf74f8f8f6f74650af4b3 DOI: 10.1128/AAC.00099-10 DOCUMENT TYPE: Article SOURCE: Scopus Schreuder, M.F., Wilhelm, A.J., Bökenkamp, A., Timmermans, S.M.H., Delemarre-van De Waal, H.A., Van Wijk, J.A.E. Impact of gestational age and birth weight on amikacin clearance on day 1 of life (2009) Clinical Journal of the American Society of Nephrology, 4 (11), pp. 1774-1778. Cited 24 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-73449123001&doi=10.2215%2fCJN.02230409&partnerID=40&md5=61177a6b15a811e82d16fdd8da36a74a DOI: 10.2215/CJN.02230409 DOCUMENT TYPE: Article SOURCE: Scopus Jelliffe, R., Schumitzky, A., Bayard, D., Leary, R., Botnen, A., Van Guilder, M., Bustad, A., Neely, M. Human genetic variation, population pharmacokinetic - Dynamic models, Bayesian feedback control, and maximally precise individualized drug dosage regimens (2009) Current Pharmacogenomics and Personalized Medicine, 7 (4), pp. 249-262. Cited 5 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-73649092728&partnerID=40&md5=817b9c58b4b9b31e6e1d9c2fc1fda962 DOCUMENT TYPE: Review SOURCE: Scopus Eggink, R.N., Duisenberg-van Essenberg, M., Lenderink, A.W. Volume of distribution of tobramycin in elderly patients [Rekenen met een kleiner verdelingsvolume? Tobramycinedosering bij oudere patiënten] (2008) Pharmaceutisch Weekblad, 143 (38), pp. 163-166. https://www.scopus.com/inward/record.uri?eid=2-s2.0-53549111056&partnerID=40&md5=ec38088cb4a6a8ee71c6f0fa66a3590b DOCUMENT TYPE: Article SOURCE: Scopus Pullen, J., Stolk, L.M.L., Degraeuwe, P.L.J., Van Tiel, F.H., Neef, C., Zimmermann, L.J.I. Pharmacokinetics of intravenous rifampicin (rifampin) in neonates (2006) Therapeutic Drug Monitoring, 28 (5), pp. 654-661. Cited 10 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-33749817451&doi=10.1097%2f01.ftd.0000245382.79939.a4&partnerID=40&md5=5685645e84a72e0ae34bf27969e4d85c DOI: 10.1097/01.ftd.0000245382.79939.a4 DOCUMENT TYPE: Article SOURCE: Scopus Stolk, L.M.L., Degraeuwe, P.L.J., Nieman, F.H.M., De Wolf, M.C., De Boer, A. Population pharmacokinetics and relationship between demographic and clinical variables and pharmacokinetics of gentamicin in neonates (2002) Therapeutic Drug Monitoring, 24 (4), pp. 527-531. Cited 32 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036340609&doi=10.1097%2f00007691-200208000-00011&partnerID=40&md5=1543b29d8a7cc87528fcaf405032731b DOI: 10.1097/00007691-200208000-00011 DOCUMENT TYPE: Article SOURCE: Scopus Tesfaye, H., Šedivý, J., Morávek, J., Sechser, T. Impact of therapeutic drug monitoring on further treatment: Retrospective study (2002) Klinicka Biochemie a Metabolismus, 10 (2), pp. 118-121. https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036242690&partnerID=40&md5=6221da5ec3d00935c4d93f92454fc88f DOCUMENT TYPE: Article SOURCE: Scopus Hunt, A., Joel, S., Dick, G., Goldman, A. Population pharmacokinetics of oral morphine and its glucuronides in children receiving morphine as immediate-release liquid or sustained-release tablets for cancer pain (1999) Journal of Pediatrics, 135 (1), pp. 47-55. Cited 56 times. https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033498336&partnerID=40&md5=742416da2038b4c36a51e11a528a3b79 DOCUMENT TYPE: Article SOURCE: Scopus Gray, R.A., Vander Velde, D.G., Burke, C.J., Manning, M.C., Russell Middaugh, C., Borchardt, R.T. Delta-sleep-inducing peptide: solution conformational studies of a membrane-permeable peptide (1994) Biochemistry, 33 (6), pp. 1323-1331. 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MwPharm++ is an efficient TDM software primarily to establish proper dosing regimen based on population PK.
read moreMwPharm Online Calculator is ideal tool for initial dose adjustment based on patient physiology and approate package size selection.
read moreMwPharm Revision System enables better control, more effective treatment and cost savings.
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