MwPharm++/Edsim++ Release 1.9.8 - Description

• Solved: The performance issue with TGamma
• Solved: The performance issue with TGaussian
• Solved: The performance issue with TWeibull
• Added: TGamma input has a new option called Smod, which stands for “Smart Events Mode”
• Solved: Crash when pressing "_" (next dose date) in the presence of extra covariates
• Solved: Profile option in simulation screen not working in case of a date scale on the X-axis.
• Solved: The [Exact] button generated an irregular regimen with an incorrect interval time (which was not used because Ndos=1)
• Solved: Cannot select variables in TPolyExp object
• Solved: The population Pna and Pma were not updated in the Edsim++ GUI after changing population age.
• Solved: Do not automatically exclude 0-observations in case of TIntVariables (including TTabVariables). These are covariates
• Solved: Edsim++ ignored the gender when importing (patient merge) EDX files
• Solved: Gamma inputs cannot be fitted when Smart Events is on.
• Added: Added "Level" mode to TAbsorptionNL in order to change the bioavailability based on the dose above that level (Dref/Plev)
• Added: Included "State" variable (XBinary) in the list of observable concentrations (Obs tab)
• Added: Active events are now stopped automatically after their contribution drops below a preset level (e.g. TGamma)
• Added: Added confidence interval (CI) calculation to general purpose Moments class
• Added: When importing patients in Edsim++, plasma concentration observations (C01.C) will be copied to a TPolyExp object PK (if present)
• Solved: The distribution type ("normal", "log-normal") of common parameters was always reported as "normal"
• Solved: KinPop++ ignored the gender in the patient data source files when importing EDX files (not XLS files). This affected the calculated creatinine clearance
• Added: Implemented bootstrap procedure
• Added: The computer is prevented from entering sleep mode during population or bootstrap analysis