MwPharm++/Edsim++ Release 1.9.4 - Description

• Solved: Parameter or variable values lost when switching between Par/Var tab after viewing "NoPop" objects in ALL-mode
• Solved: Error when adding regimen to empty medication history
• Solved: An observation at exactly the time of an IV bolus injection is interpreted as a peak and not as a trough
• Solved: The RSE value in the statistics module was calculated incorrectly as SE
• Solved: Clicking the SD checkbox in the Obs tab should directly refresh the variable listboxes (no need to change tabs first)
• Solved: Listbox cycling (space bar) and selection (key press) not responsive anymore
• Solved: QInput and QOutput should use Substance from associated TResponse object
• Solved: TVirtualLinked now also takes baseline concentrations into account
• Solved: Observation user errors (Var.Sd) were never stored/read to/from EDX files
• Solved: Added exclusive ON state group check for XBinary objects just prior to a simulation
• Solved: Allow the calculation of 95%-CI of all observed variables except (TReference) . This includes all AUC variables in TIntegerator
• Added: TGammaNL object for modeling dose dependent bioavailability using sigmoidal or power functions
• Updated: Wrap demo entry "Unit" for quantity "None" in Edsim++.units file ("Unit") in an XML-Comment
• Updated: Changing the Quantity of an XObserved from "None" to "Fraction" does not work (displayed units are the same, "-")
• Updated: When saving the model, the diagram window should be shown before attempting to build the model
• Updated: Redesigned QAbsDT class and renamed to TAbsorptionNL. Better implementation modelled after TGammaNL using internal covars.
• Updated: Redesigned QAbsSIN class. More elegant implementation using internal covariate that leaves functionality of TAbsorption intact.
• Added: Alternative bioavailabiliy parametrization for TInputEV and TDist in which F represents absorbed or unabsorbed fraction
• Solved: Do not throw "All parameters are fixed" and "No observations to fit" exceptions for a fit in KinPop++ context
• Added: Added PopFitSD (fit population SD value) property to Parameter class in order to support KinPop++ (see also CR-288).
• Updated: Split ODE mode into ODE-E0 (E0=Kin/Kout), ODE-KIN (Kin=E0*Kout) and ODE-KOUT (Kout=Kin/E0)
• Added: New units to Length quantity (mm, µm and nm)
• Added: Add Quantity option to Emax model TSigmoid
• Updated: TCompartment.C0 is now set to unity value in case it was 0 and fitted (see CR-204, 1E-10 was too small)
• Updated: Regimen insertion overlap detection has been changed. For ON events inclusive event time, for OFF events exclusive event time
• Added: TInfusionEV object for modeling extravenous infusions like subcutaneous infusions
• Updated: Included elimination (excretion) rate R as a variable for which observations may be entered (e.g. for urine data)
• Updated: Redesigned TAbsorptionN (transit absorption) for allowing TInfusionEV and other inputs to be connected
• Added: TDisplacer transfer object (modeled after TDisplacement) for modeling protein displacement in two TPCompartments
• Added: TClearance and TTissue objects (can replace TElimination and TPeripheral)
• Updated: A XCovariate (transformer) object cannot be connected to a TMonitor object
• Updated: Event/Observation (en)(dis)abling (toggling) can now be done on a selected range (space or contrext menu) instead of one cell
• Added: MwPharm support for user defined per-observation standard deviations by adding RSD variable to TExtWeighting
• Added: PGx model design (3, 4 or 5 levels) pattern (Model > Insert > PGx )