MwPharm++/Edsim++ Release 1.9.0 - Description

• Added: Reference value (Vref) to XExponential covariate transform.
• Added: Exponential sign (Esig) to XExponential and XScaler (0=positive (default), 1=negative)
• Added: New maturation class (XMaturation) combining sigmoidal and exponential maturation driven by PNA or PMA
• Added: New units (1/month, 1/week and 1/day) to dynamic quantity AgeRate in XAgeSex class for use in XMaturation class
• Added: Pna variable to XPatient(Ex), which is identical to the Age variable (can be used with a different unit like days)
• Added: AgeRate quantity to list of quantities with corresponding units (1/year, 1/month, 1/week, 1/day).
• Added: "Monitor ODE error" option to QResponse. Allows disabling of ODE error monitoring in case this causes problems (def. ON).
• Added: "Assume steady state" option to QResponse. Allows initializing response to E0=Kin/Kout (else E0=0)
• Added: TWeibull2 and TGauss2 classes (in addition to TGamma2) for biphasic input profiles. A TAbsorption2 is not possible.
• Added: Option symbols can now also be hidden by a subclass
• Added: QInhibitor and QStimulator QSP objects derived from TSigmoid effect
• Added: Variable name array (Yvar) to the FitModel(Ex) class in order to keep track the source variable of an observation
• Added: XRenalFunc now updates the RF value in the connected TPatient object (XRenalFunc acts as a plugin for TPatient)
• Added: The TPolyMon object will now always report the total linear clearance (CL) and total non-linear elimination capacity (Vmax)
• Added: Increased the maximum allowed parameter name from 2 to 4 chars before displaying the parameter as an "X" button on the toolbar
• Added: Total elimination tool object TTotalCL for the calculation of the total elimination rate R and total clearance CL
• Added: TResponse has been removed from the library and has been replaced by QIn, QOut and QResponse
• Added: The list of options is completely refreshed when one option has been changed because options can affect each others visibility
• Added: QPulse and QPulse2 classes to library for modeling circadian rhythm (chronopharmacokinetics)
• Added: New quantities and units (Frequency, Force, Pressure, Energy, Power, Temperature)
• Added: In baseline mode only one TProduction may be connected to a compartment. Input rate R can now be modulated.
• Added: Use the font "striketrough" style on an observation to set the exclude flag of observations during the import of an Excel workbook
• Added: Use the font "striketrough" style on an event value to set the exclude flag of events during the import of an Excel workbook
• Added: Allow a TKinFit object to change the substance (and thus molecular weight)
• Updated: Extended TMonitor class. Monitored variable now limited to Min/Max limits and can also be used as a covariate now.
• Solved: Trim strings during import of Excel files in order to eliminate trailing/leading spaces or spaces-only strings
• Solved: XExponential rate unit k should be the reciprocal of the scaler unit and set as read-only
• Solved: PolExp and DosLib libraries should not generate (internal) exceptions in case of a null clearance
• Solved: The TWeibull time factor parameter is not dimensionless. The unit should 'h' (hours)
• Solved: No patient box clearance reported in status screen in case of non-standard inputs (e.g. TGamma).
• Solved: Object reflection routine.
• Solved: XRenalFunc only works with observed creatinine levels. The current value in the absence of creatinine levels is ignored
• Solved: Cannot change the unit of a parameter with an assigned covariate because the quantity is reset to None
• Solved: MwPharm++/Edsim++ crashes in case two objects are given the same name
• Solved: Selecting an existing substance does not copy the molecular mass. Instead, the molecular mass is set to the current value.
• Solved: Importing an Excel file should never overwrite an existing model variable alias.
• Solved: Columns labeled with a variable alias name were ignored during the Import of an Excel file.
• Solved: Generic covariates are exported to 2 columns. One with the alias name (with data) and one with the full name (no data)
• Solved: Generic covariates should not be exported to the index sheet (only the data sheet)
• Solved: Event values using a non-standard unit are incorrectly interpreted during the import of Excel files
• Solved: Excluded lines (EX=1) should not contribute to history start date (HSD) determination during the import of Excel files
• Solved: Dose Min/Max boosting did not work well for single dosages, PO dosages and non-linear PK